Contraindicated (1)pentobarbital will lower the extent or outcome of cariprazine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. CYP3A4 is answerable for the development and elimination of cariprazine's Lively metabolites.pentobarbital will lessen the level or effect of eltrombopag by influencing hepatic enzyme CYP2C9/ten

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